Will talk about: Systems and synthetic biology of biological timings
Dr. Hiroki R. Ueda was born in Fukuoka, Japan, in 1975. He graduated from the Faculty of Medicine, the University of Tokyo, in 2000, and obtained his Ph.D in 2004 from the same university. While an undergraduate student, he worked as a research assistant on a biological simulation system project at Sony Computer Science Laboratories. While a graduate student, he next went on to work as a researcher from 2000 and then group leader from 2002 at Yamanouchi Pharmaceutical Co.
He was appointed as a team leader of laboratory for systems biology at RIKEN Center for Developmental Biology (CDB) from April, 2003 and promoted to be a project leader at CDB from September, 2009. He was also appointed as a manager of Functional Genomics Unit at the CDB from October, 2004. He also became a visiting professor in Tohoku University in April, 2005-March, 2006, Tokushima University from April, 2005 and National Institute of Genetics from April, 2010, and an invited professor of biology in Osaka University from April, 2006, and an invited professor of mathematics in Kyoto University from April, 2009.
He identified system-level network structure of mammalian circadian clocks. For this discovery, He received Tokyo Techno Forum 21, Gold Medal (Tokyo Techno Forum 21, 2005), Young Investigator Awards (MEXT, 2006) and IBM Science Award (IBM, 2009). He recently solved the fundamental problem in chronobiology on the underling mechanism of singularity behavior of circadian clock that had been unsolved for more than 30 years. For this discovery, he received a Young Investigator Promotion Awards (Japanese Society for Chronobiology, 2007). He also recently discovered temperature-insensitive reaction in mammalian circadian clock, which will lead to a long-standing problem, "temperature-compensation" of circadian clock. He invented diagnostic method of body time and rhythm disorders, which opens up the new possibility of chronotherapy. For this invention, he received Japan Innovator Awards (Nikkei Business Publications Inc. 2004). His current research interests include systems and synthetic biology of biological timings.
The logic of biological networks is difficult to elucidate without (1) comprehensive identification of network structure, (2) prediction and validation based on quantitative measurement and perturbation of network behavior, and (3) design and implementation of artificial networks of identified structure and observed dynamics.
Mammalian circadian clock system is such a complex and dynamic system consisting of complicatedly integrated regulatory loops and displaying the various dynamic behaviors including i) endogenous oscillation with about 24-hour period, ii) entrainment to the external environmental changes (temperature and light cycle), and iii) temperature compensation over the wide range of temperature. In this symposium, I will take a mammalian circadian clock as an example, and introduce the systems- and synthetic-biological approaches for understanding of biological timings.
1. Ueda, H.R. et al, Nature 418, 534-539 (2002).
2. Ueda, H.R. et al, Nat. Genet. 37, 187-92 (2005).
3. Sato T. K. et al, Nat Genet. 38, 312-9 (2006).
4. Ukai H. et al, Nat Cell Biol. 9, 1327-34 (2007).
5. Ukai-Tadenuma M. et al, Nat Cell Biol. 10, 1154-63 (2008).
6. Minami Y. et al PNAS 106, 9890-5 (2009).
7. Isojima Y. et al, PNAS 106, 15744-49 (2009).
8. Masumoto KH. et al, Curr Biol.20(24):2199-206.(2010).
9. Ukai-Tadenuma M et al. Cell 144(2):268-81 (2011).
10. Hogenesch JB, Ueda HR. Nature Rev. Genet. 12(6):407-16 (2011). 11. Jolley Cc, Ode KL, Ueda H.R. Cell Reports 2(4):938-50 (2012).